NAD+ / B12

NAD+ (Nicotinamide Adenine Dinucleotide) is a fundamental coenzyme present in every living cell, serving as an obligate electron carrier in mitochondrial respiration and ATP production. This high-dose 1000 mg formulation is co-complexed with methylcobalamin (Vitamin B12) to support one-carbon metabolism, methylation pathways, and neurological function.

In longevity and cellular-health research, NAD+ is investigated for its role as a substrate for sirtuins and PARP enzymes—families of proteins that govern DNA repair, genomic stability, mitochondrial biogenesis, and cellular stress responses. Declining NAD+ levels are correlated with aging phenotypes; therefore, restoring NAD+ pools is a central strategy in geroscience research. Methylcobalamin B12 complements this by supporting myelin synthesis, neurotransmitter production, and homocysteine regulation.

Research applications include studies on mitochondrial dysfunction, cognitive performance, chronic fatigue models, cellular senescence, and metabolic health. This formulation provides a robust substrate for investigations into the biology of aging, energy metabolism, and neuroprotection. For research purposes only.